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Year : 2021  |  Volume : 15  |  Issue : 3  |  Page : 77-79

Polyneuropathy as paraneoplastic syndrome in a patient with metastatic diffuse large B-cell lymphoma

1 Department of Dermatology and Venereology, Hacettepe University, School of Medicine, Ankara, Turkey
2 Department of Pathology, Hacettepe University, School of Medicine, Ankara, Turkey

Correspondence Address:
Dr. Ecem Bostan
Department of Dermatology and Venereology, Hacettepe University, Faculty of Medicine, Ankara.
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/tjd.tjd_38_21

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Paraneoplastic syndromes are multisystemic diseases that are seen in association with solid organ tumors and lymphomas. Immune-mediated polyneuropathy, encephalopathy, cerebellar degeneration, and Guillain–Barre syndrome have all been described as paraneoplastic neurologic disorders. Clinical symptoms may appear before the diagnosis of associated malignancy creating diagnostic confusion. Tumor-derived peptides, hormones, and mediators are shown to be associated with paraneoplastic syndromes. Herein, we present an unusual case of stage 4 diffuse large B-cell lymphoma with cutaneous metastatic nodules presenting initially as paraneoplastic polyneuropathy.

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