• Users Online: 145
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2022  |  Volume : 16  |  Issue : 2  |  Page : 38-43

A retrospective study of skin biopsies of 184 cutaneous lichen planus patients


Department of Dermatology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Hari Shivaram Pathave
Department of Dermatology, KJ Somaiya Medical College, Mumbai 400022, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/tjd.tjd_116_21

Rights and Permissions

Background: Lichen planus (LP) is a chronic inflammatory and immune-mediated disease characterized by multiple clinical presentations. There are very few studies analyzing histopathological features of LP worldwide. Objectives: The aim of this work was to study different histopathological patterns in skin biopsies of LP and to correlate the clinical and histopathological features. Materials and Methods: Records of 184 biopsies diagnosed as LP were included in the study. Clinical data from the records reviewed. Hematoxylin and eosin-stained sections were retrieved, re-examined, and histopathological parameters were noted. Results: Among the 184 biopsies of LP patients, pigment incontinence (93.5%) was the most common followed by hypergranulosis (88%) and interface dermatitis (82.6%). In epidermal changes, saw-toothed acanthosis (90, 48.9%) was the most common followed by the flattened epidermis (47, 25.5%), irregular moderate acanthosis with appendageal involvement (31, 16.9%), and pseudocarcinomatous hyperplasia (16, 8.7%). In tissue reaction patterns, the lichenoid pattern was the most common (131, 71.2%) followed by mild superficial perivascular dermatitis (MSPVD) in 20 (10.9%) followed by various combination patterns. The types of hypergranulosis seen were wedge-shaped (86, 53.1%) followed by infundibular (32, 19.8%), regular (30, 18.5%), and acrosyringeal (14, 8.6%). Changes of venous stasis were observed in 41% of lower limb biopsies. Conclusion: On histopathology, pigment incontinence and hypergranulosis were the most consistent features in all types of LP. Awareness about the less frequent patterns may improve the diagnostic accuracy of clinicopathologic correlation.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed308    
    Printed4    
    Emailed0    
    PDF Downloaded38    
    Comments [Add]    

Recommend this journal