• Users Online: 425
  • Print this page
  • Email this page
Year : 2022  |  Volume : 16  |  Issue : 3  |  Page : 80-86

Retrospective analysis of cases with Stevens-Johnson syndrome/toxic epidermal necrolysis: A case series of 20 patients

1 Akdeniz University, Department of Dermatology and Venereology, Antalya, Turkey
2 Akdeniz University, Department of Ophthalmology, Antalya, Turkey
3 Akdeniz University, Department of Pediatrics, Intensive Care Subunit, Antalya, Turkey
4 Akdeniz University, Department of Anesthesia and Reanimation, Antalya, Turkey

Correspondence Address:
Assoc. Prof. Aslı Bilgiç
Akdeniz University Faculty of Medicine, Department of Dermatology and Venereology, H Bloc, 1 Floor, 07059 Konyaaltı, Antalya
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/tjd.tjd_13_22

Rights and Permissions

Background: Stevens-Johnson syndrome (SJS)/ toxic epidermal necrolysis (TEN) are rare, acute, severe cutaneous hypersensitivity reactions usually triggered by medications. They are classified by the extent of the detached skin surface area. Objective: We aimed to retrospectively evaluate the sociodemographic, clinical, therapeutic, and prognostic characteristics of SJS/TEN cases diagnosed between January 2015 and December 2020 in our centre. Materials and Methods: All the data regarding patient characteristics were obtained retrospectively. The SCORe of Toxic Epidermal Necrolysis (SCORTEN) was used to predict disease severity and mortality rates. Results: Out of 20 patients (14 females, 6 males), eight (40%) were evaluated as TEN, three (15%) as SJS/ TEN overlap, and nine (45%) as SJS. The mean age was 39.2 ± 27.92 years. A higher frequency of systemic antibiotic use was found in cases of SJS/TEN overlap or TEN compared to SJS cases during patients’ follow-up after the diagnosis (P = 0.006). The most common responsible drug was allopurinol (25%). While the estimated mortality in patients with SCORTEN values of 4 and 5 was 58.3% and 90.0%, the mortality observed in our cohort was 50% and 100%, respectively. In terms of complications, ocular problems were the most common ones. Ophthalmic sequelae were observed in 15 patients during the follow-up period, the most common belonging to the cornea. Conclusion: In conclusion, early diagnosis, immediate discontinuation of suspected drugs, and good clinical care are among the most crucial treatment steps in the treatment of SJS/TEN. In addition, multidisciplinary management of the disease is vital in preventing the development of long-term sequelae in survivors.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded155    
    Comments [Add]    

Recommend this journal