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  Indian J Med Microbiol
 

Figure 2: On low-power lymphoid neoplasm centered around skin adnexae in dermis with concomitant subcutaneous fat involvement was seen (A) (HandE, 40X). Neoplastic population was composed of medium-sized atypical lymphoid cells with blastic chromatin, irregular nuclear contours and small nucleoli (B) (HandE, 200X). Immunohistochemically these cells were diffusely and strongly positive with CD20 (D, 400X), Bcl-2 (E, 400X). Ki-67 proliferation index was relatively (%80) high (F, 400X). Findings supported a high-grade B cell lymphoma, for further subclassification FISH was performed. On FISH examination neoplastic cells showed a pattern consistent with MYC gene translocation (C, 1000X). Together with the immunophenotypic and morphological findings the patient was finally diagnosed as MYC-positive diffuse large B cell lymphoma

Figure 2: On low-power lymphoid neoplasm centered around skin adnexae in dermis with concomitant subcutaneous fat involvement was seen (A) (HandE, 40X). Neoplastic population was composed of medium-sized atypical lymphoid cells with blastic chromatin, irregular nuclear contours and small nucleoli (B) (HandE, 200X). Immunohistochemically these cells were diffusely and strongly positive with CD20 (D, 400X), Bcl-2 (E, 400X). Ki-67 proliferation index was relatively (%80) high (F, 400X). Findings supported a high-grade B cell lymphoma, for further subclassification FISH was performed. On FISH examination neoplastic cells showed a pattern consistent with MYC gene translocation (C, 1000X). Together with the immunophenotypic and morphological findings the patient was finally diagnosed as <i>MYC-positive diffuse large B cell lymphoma</i>